Weight Loss Pills - History of Fen-Phen
Weight Loss Pills Article
History Of Fen-Phen
Phentermine is an appetite suppressant that makes up half of the prescriptions written today. It is cheaper than the alternative drugs Meridia and Xenical. It was first approved by the FDA in 1959 for short-term treatment of obesity. Trials were done in the early 1990s on the combination of Phentermine and Fenfluramine which made up Fen-Phen. Fenfluramine had received FDA approval in 1973 for the short-term treatment of obesity. Combined, Fen-Phen was a powerful mixture, but was never approved together by the FDA. Since the two parts had each been granted FDA approval, doctors had the authority to prescribe them together, which was considered 'off-label'.Dr. Michael Weintraub of the University of Rochester published a study in 1992 showing that Fen-Phen was a more effective method than dieting or exercise in reducing the weight of the chronically obese. And, it did not show any immediate side effects like the other weight loss pills of the time. Overnight, prescriptions of the combined drugs jumped to over six million per year.
Dexfenfluramine was granted FDA approval in 1996 for use as an appetite suppressant in the management of obesity. Dexfen-Phen was another combination that became an overnight sensation, just like Fen-Phen. Unfortunately, neither combination was ever tested for safety. In the summer of 1997, the Mayo Clinic reported that they had found 24 cases of heart valve disease and that all 24 had taken the Fen-Phen combination. They believed that the unusual number of heart valve disease cases in Fen-Phen users suggested a relationship.
On July 8, 1997, the FDA issued a Public Health Advisory to report the Mayo Clinic findings. The FDA received further reports of users with heart disease. Some of the subjects had taken only Fenfluramine or Dexfenfluramine.
Additional findings showed that 30% of the patients taking Fenfluramine or Dexfenfluramine had abnormal valve conditions. The number was statistically too high for normal correllation and suggested Dexfenfluramine and Fenfluramine were the likely causes of the heart disease. The FDA requested in September, 1977 that drug manufacturers voluntarily take Fenfluramine and Dexfenfluramine off the market and that paients with supplies of either drug stop taking them. It has since been found that there were a considerable number of users that suffered heart disease due to taking these prescriptions.
There were never any findings implicating Phentermine with the heart disease. Weight loss pills are often hard to pass up. Weight loss pills can cause more harm than good. Consult a doctor for weight loss supplements that are available only by prescription.
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